Mercury Chelation, Why a Suppository?

Effects of CaNa2 EDTA (Detoxamin®) Suppositories on Excretion of Heavy Metals, Living Longer Institute, Cincinnati, Ohio

The body sequesters mercury Hg in the liver by binding it to cholesterol and converting it into bile that then flows into the intestines. As bile is used to breakdown dietary lipids, some of the Hg becomes unbound in the intestinal tract. Detoxamin CaNa2-EDTA Suppositories deliver the mercury chelation ability just where the maximum Hg excretion is taking place.
  • The EDTA has more opportunities to bind to heavy metals. Through galvanic series of metals & alloys, the EDTA has greater opportunities to bind with heavy metals closer to the cathodic end of the series.
  • The maximum amount of recommended EDTA in one week to be spaced out into nightly treatment, greatly enhancing the chelation efficacy of Detoxamin CaNa2-EDTA. With traditional IV EDTA chelation, physicians and nursing staff need to be constantly vigilant for blood serum calcium deficiency.

Significant excretion was observed (P< 0.05) with cumulative CaNa2 EDTA therapy of Day 3 and Day 90 compared to Day 0 with lead, arsenic, cadmium (Figure 1) and nickel (Figure 2) in fecal samples. In addition, statistically significant cumulative excretions (P< 0.05) in arsenic, lead, mercury, cadmium and nickel in urine samples (Figure 3) were found. There were no differences in the safety profile comparisons within comprehensive metabolic chemistry panels between pre- and post-treatment blood values. Only minor transient complaints of loose stools and gas were reported in several subjects. Calcium disodium EDTA suppositories (Detoxamin) appear to be a safe and effective means to slowly and consistently remove a variety of toxic heavy metals, as evidenced by urine and fecal analysis.

Mercury chelation results

The safety and efficacy of a recently developed suppository delivery of CaNa2 EDTA. Suppositories provide direct access to the systemic circulation, efficiently bypassing portal circulation and liver metabolism via the hemorrhoidal veins on the first pass. The study examined the ability of CaNa2 EDTA suppositories to remove a variety of the most prevalent toxic heavy metals as determined by excretion in urine and feces and also looked at it's unique mercury chelation ability.

Detoxamin CaNa2-EDTA Suppositories provide a safe and effective alternative to the expensive and invasive traditional slow drip EDTA protocol for metal detoxification. The fact that CaNa2-EDTA administered rectally might be an effective means for mercury chelation Hg detoxification is in sharp contrast to the relative inefficiency of traditional EDTA mercury chelation, which is based upon urinary excretion.

edta suppositories

Why a suppository for mercury chelation?

Within the era of cost-containment and the risk of AIDS and other communicable blood-borne diseases, time constraints and affordability issues, suppository drug delivery is becoming a more viable option for doctors and patients. Suppositories provide direct access to the systemic circulation, efficiently bypassing the portal circulation and the liver metabolism on the first pass. It is a little known fact that the lower and middle hemorrhoidal veins bypass the liver and do not undergo first-pass metabolism. Therefore, suppositories can deliver the drug rapidly to the lower and middle hemorrhoidal veins for absorption. The rectum is an interesting area for drug absorption because it is not buffered and has a neutral pH. It also has very little enzymatic activity, thus enzymatic degradation does not occur. The rectal mucosa is more capable than the gastric mucosa of tolerating various drug-related irritations. This is especially important in patients with gastric disease. The anorectal physiology provides a large surface area for drug absorption. Another factor that is important in drug delivery is drug solubility. The osmosis process allows the drug to transfer from the vehicle in the suppository, across the membrane of the rectum, and into the hemorrhoidal veins. As we become more aware of the potential complications of infection associated with the use of IVs, suppository administration provides a preferable alternative.

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